Education:

Fellowship: Wills Eye Hospital, Philadelphia, Pennsylvania
Vitreoretinal Fellowship
July 2000 – June 2002

Residency: Medical College of Wisconsin Eye Institute
Milwaukee, Wisconsin
Ophthalmology Residency
July 1997 – June 2000
Chief Resident
July 1999 – June 2000

Internship: St Luke’s Medical Center
Milwaukee, Wisconsin
Transitional Internship
July 1996 – June 1997

Medical School: Northwestern University Medical School
Chicago, Illinois
Doctor of Medicine
September 1992 – June 1996

Undergraduate: Northwestern University
Evanston, Illinois
Bachelor of Arts, Honors Graduate
Chemistry Major
September 1988 – June 1992

Board Certification: United States Medical Licensing Examination
June 1994, March 1996, May 1997

Medical License: California A78255

Honorary Societies: Alpha Omega Alpha National Medical Honor Society

Awards, Honors, and Scholarships:

1996 Phi Rho Sigma George Dennis Award
1996 American College of Physicians Award Finalist for Medicine
1992 Chemistry Department Scholar Award
1991 William J. Cook Scholarship
1991 William H. Mellick Scholarship

Refereed Publications:

Sharma MC, Regillo CD, Shuler MF, Borrillo JL, Benson WE. Determination of the incidence and clinical characteristics of subsequent retinal tears following treatment of acute posterior vitreous detachment-related intial retinal tears. Am J Ophthalmol 2004; 138(2):280-284

Borrillo JL, Sivalingam A, Martidis A, Federman JL. Surgical ablation of retinal angiomatous proliferation. Arch Ophthalmol 2003;121(4):558-561

Tennant MT, Borrillo JL, Regillo CD. Management of submacular hemorrhage. Ophthalmol Clin North Am. 2002;15(4):445-452

Borrillo JL, Regillo CD. Treatment of Subretinal Hemorrhages with Tissue Plasminogen Activator. Curr Opin Ophthalmol 2001;12:207-211

Shuler M, Borrillo JL, Ho AC. Photodynamic Therapy Update. Curr Opin Ophthalmol 2001:12:202-206

Mittra RA, Borrillo JL, Dev S, Koenig SB, Mieler WF. Retinopathy progression and visual outcomes after phacoemulsification in patients with diabetes mellitus. Arch Ophthalmol. 2000; 118:912-917

Wirostko WJ, Mittra RA, Rao PK, Borrillo JL, Mieler WF. The use of surgical instrumentation for macular translocation in a rabbit and pig model. Amer J Ophthalmol. 2000; 129:549-551

Silverman RB, Ding CZ, Borrillo JL, Chang JT. Mechanism-based enzyme inactivation via a diactivated cyclopropane intermediate. Journal of the American Chemical Society. 1993; 115:2982-2983

Publications:

Borrillo JL, Shuler M, Ho AC. Photodynamic therapy update. Current Concepts in Ophthalmology (Pennsylvania Academy of Ophthalmology) 2001; 9:36-38

Borrillo JL, Sivalingam A. Diabetic retinopathy in pregnancy. Current Concepts in Ophthalmology (Pennsylvania Academy of Ophthalmology) 2001; 9:59-62

Major Research Activities and Clinical Trials:

2004-present A six month, Phase III, multicenter, masked, randomized, sham-controlled trial (with six-month open-label extension) to assess the safety and efficacy of 700mg and 350 mg dexamethasone posterior segment drug delivery system (DEX PS DDS) applicator system in the treatment of patients with macular edema following central retinal vein occlusion or branch retinal vein occlusion. Northern California Retina-Vitreous Associates, Mountain View, California.

2003-present A Phase III, multicenter, randomized, double-masked, active treatment-controlled study of the efficacy and safety of rhuFab V2 (Ranibizumab) compared with verteporfin (Visudyne) photodynamic therapy in subjects with predominantly classic subfoveal neovascular age-related macular degeneration. Northern California Retina-Vitreous Associates, Mountain View, California. (Co-investigator) Funded by Genentech, Inc.

2000-2002 An evaluation for safety and efficacy of anecortave acetate sterile suspension versus placebo following a single sub-tenon’s injection for the inhibition of choroidal neovascularization in patients with exudative age-related macular degeneration. Retina Clinical Research Unit, Wills Eye Hospital (Co-investigator), Funded by Alcon Pharmaceuticals

2000-2002 Purlytin photodynamic therapy for choroidal neovascularization: a multicenter clinical trial. Retina Clinical Research Unit, Wills Eye Hospital (Co-investigator), Funded by Miravant and Pharmacia-Upjohn

2000-2002 Intravitreal vitrase (hyaluronidase) injection for clearance of severe vitreous hemorrhage: a multicenter clinical trial. Retina Clinical Research Unit, Wills Eye Hospital (Co-investigator), Funded by Advanced Corneal Systems

2000-2002 A phase IB open-label multi-center trial to establish the safety and pharmacokinetic profile of three consecutive injections of EYE001 (Anti-VEGF pegylated aptamer) in patients with age related macular degeneration. Retina Clinical Research Unit, Wills Eye Hospital (Co-investigator), Funded by EyeTech Pharmaceuticals

2001-2002 A phase III clinical trial for protein kinase C b inhibitor-diabetic retinopathy study 2 (PKC-DRS2); protocol B7A-MC-MBCM. Retina Clinical Research Unit, Wills Eye Hospital (Co-investigator), Funded by Eli Lily

2001-2002 A Phase II Randomized, open-label, multicenter, controlled trial to assess the safety and efficacy of dexamethasone posterior segment drug delivery system (DEX PS DDS) in the treatment of persistent macular edema. Retina Clinical Research Unit, Wills Eye Hospital (Co-investigator), Funded by Oculex Pharmaceuticals

Book Chapters:

Borrillo JL, Vander J. Surgical management of exudative retinal detachments. In: Tasman W, Jaeger E (Eds), Duane’s Ophthalmology. In Press

Mieler WF, Borrillo JL. Epidemiology and Prevention of Ocular Injuries. In: Albert DM, Jakobiec FA (Eds). The Principles and Practice of Ophthalmology 2nd Ed. Philadelphia: WB Saunders 2000

Grants:

Wirostko WJ, Mittra RA, Rao PK, Borrillo JL, Mieler WF. The use of surgical instrumentation for macular translocation in a rabbit and pig model. July 1998

Wirostko WJ, Mittra RA, Rao PK, Borrillo JL, Mieler WF. The use of surgical instrumentation for macular translocation in a cadaver eye model. June 1998

Abstracts/Presentations:

Borrillo JL, Boldrey EE, Maberley AL. Patient preference: Foveal ablation versus PDT for subfoveal CNV. (Poster) Annual Meeting of the American Academy of Ophthalmology, Anaheim, California. November 2003.

Boldrey EE, Borrillo JL. Foveal ablation versus photodynamic therapy in select patients. American Society of Retina Surgeons. New York, New York. Summer 2003.

Borrillo JL, Sivalingam A, Martidis A. Surgical ablation of retinal angiomatous proliferation. Annual Spring Meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida. May 2002

Borrillo JL, Sivalingam A, Martidis A. Surgical lysis of retinal angiomatous proliferation. Annual Wills Conference. Philadelphia 2002

Borrillo JL, Dev S, Connor TB. Outcomes after anterior chamber intraocular lens placement in patients with diabetes mellitus. (Poster) Annual Spring Meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida. May 2000

Borrillo JL, Mittra RA, Dev S, Rao PK, Pescinski S, Prasad A, Koenig SB, Mieler WF. Retinopathy progression and visual outcomes after phacoemulsification in patients with diabetes mellitus. (Poster) Annual Spring Meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida. May 1999

Logani S, Borrillo JL, Schroeder RP, Weinberg DV, Jampol LM, Small W, Johnson P, Shetty RM. Intraoperative ultrasonographic verification of radioactive plaque localization in the treatment of choroidal melanoma. International Congress of Eye Tumors, Wills Eye Hospital, Philadelphia, Pennsylvania. May 1999

Mittra RA, Borrillo JL, Dev S, Rao PK, Mieler WF, Koenig SB. Retinopathy progression and visual outcomes after phacoemulsification in patients with diabetes mellitus. American Ophthalmological Society, Santa Barbara, California. May 1999

Logani S, Schroeder RP, Weinberg DV, Jampol LM, Borrillo JL. Intraoperative ultrasonographic verification of radioactive plaque localization in the treatment of choroidal melanoma. (Poster) Annual Meeting of the American Academy of Ophthalmology, Chicago, Illinois. October 1996

Other Presentations:

Borrillo JL. Retinal Unknowns I & II. Osler Institute Review Course. San Francisco, CA. June & October 2006

Borrillo JL. AMD update. Philippine Medical Association of Chicago. Lisle, IL. March 2006.

Borrillo JL. Retinal Unknowns I & II. Osler Institute Review Course.
San Francisco, California. Winter 2004

Borrillo JL. Age Related Macular Degeneration. ASORN.
Palo Alto, California. September 2004

Borrillo JL. Retinal Unknowns I & II. Osler Institute Review Course.
San Francisco, California. Spring 2004

Borrillo JL. Retinopathy of Prematurity.
Good Samaritan Hospital, San Jose, California. December 2003

Borrillo JL. Diabetes and Eye Disease.
Peninsula Hospital, Burlingame, California. September 2003

Borrillo JL. Ophthalmology for Primary Care Resident Physicians.
Zablocki Veterans Hospital, Milwaukee, Wisconsin. November 1999

Borrillo JL. Eye Emergencies. Medical Student Lecture.
Medical College of Wisconsin Eye Institute, Milwaukee, Wisconsin. May 1999

Borrillo JL. Diabetic Retinopathy. Medical Student Lecture.
Medical College of Wisconsin Eye Institute, Milwaukee, Wisconsin. May 1999

Borrillo JL. The Red Eye. Medical Student Lecture.
Medical College of Wisconsin Eye Institute, Milwaukee, Wisconsin. July 1998

Borrillo JL, Mittra RA, Dev S, Rao PK, Pescinski S, Prasad A, Koenig SB, Mieler WF. Outcomes of Modern Phacoemulsification Surgery in Patients with Diabetes. Presented at the Annual Medical College of Wisconsin and University of Wisconsin Residents’ Day Program Milwaukee, Wisconsin. May 1998

Borrillo JL, Stock EL. Keratectomy Model of Bovine Cornea Wound Healing. Presented at the Annual Medical Student Research Day, Northwestern University Medical School, Chicago, Illinois. June 1993

Teaching Experience:

Retina Clinic Attending Physician, University of California San Francisco, Veterans Administration Hospital, San Francisco, California. 2004-present

Neuroanatomy Teaching Assistant, Northwestern University Medical School, Chicago, Illinois. Spring 1994

Histology Teaching Assistant, Northwestern University Medical School, Chicago, Illinois. Winter 1994

Biochemistry Instructor/Head Counselor, National High School Institute, Engineering & Science Division, Northwestern University, Evanston, Illinois. Summer 1991

Genetics Instructor/Counselor, National High School Institute, Engineering & Science Division, Northwestern University, Evanston, Illinois. Summer 1990

Leadership/Community Service:

American Academy of Ophthalmology Member 1998-present

American Society of Retina Surgeons Member 2003-present

Pennsylvania Academy of Ophthalmology Member 2000-present

Co-Chair, Resident Physician and Fellows Section, Wisconsin State Medical Society 1999-2000

Medical College of Wisconsin Affiliated Hospitals Housestaff Health and Welfare Committee Member 1998-2000

Association for Research in Vision and Ophthalmology Member 1998-2000

American Medical Association, Resident and Fellows Section 1999-2000

Philippine Medical Association of Wisconsin Member 1997-2000

Milwaukee Madison Street Clinic Volunteer 1996-1997